Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Identifieur interne : 002219 ( Main/Exploration ); précédent : 002218; suivant : 002220Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Auteurs : Jeffrey A. Lieberman ; Frank P. Bymaster ; Herbert Y. Meltzer ; Ariel Y. Deutch ; Gary E. Duncan ; Christine E. Marx ; June R. Aprille ; Donard S. Dwyer ; Xin-Min Li ; Sahebarao P. Mahadik ; Ronald S. Duman ; Joseph H. Porter ; Josephine S. Modica-Napolitano ; Samuel S. Newton ; John G. CsernanskySource :
- Pharmacological reviews [ 0031-6997 ] ; 2008.
Abstract
Various lines of evidence indicate the presence of progressive pathophysiological processes occurring within the brains of patients with schizophrenia. By modulating chemical neurotransmission, anti-psychotic drugs may influence a variety of functions regulating neuronal resilience and viability and have the potential for neuroprotection. This article reviews the current literature describing preclinical and clinical studies that evaluate the efficacy of antipsychotic drugs, their mechanism of action and the potential of first- and second-generation antipsychotic drugs to exert effects on cellular processes that may be neuroprotective in schizophrenia. The evidence to date suggests that although all antipsychotic drugs have the ability to reduce psychotic symptoms via D2 receptor antagonism, some antipsychotics may differ in other pharmacological properties and their capacities to mitigate and possibly reverse cellular processes that may underlie the pathophysiology of schizophrenia.
Url:
DOI: 10.1124/pr.107.00107
PubMed: 18922967
PubMed Central: 4821196
Affiliations:
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